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Artículo Tomo 71, Número. 3, Abril 2018

Archivos Españoles de Urología

Locally advanced prostate cancer. Definition, diagnosis and treatment.

Authors: Javier Mayor de Castro, Jorge Caño Velasco, Juan Aragón Chamizo, Guillermo Andrés Boville, Felipe Herranz Amo y Carlos Hernández Fernández.

Arch. Esp. Urol. 2018; 71 (3): 231-238

Vol. 71, Number. 3, April 2018

Prostate cancer is a disease that presents a wide spectrum from low aggressiveness localized to disseminated cancer. Locally advanced prostate cancer (LAPC) is a particularly difficult to manage phase of this spectrum.

OBJECTIVES: We review the definition, diagnosis and treatment of this phase of the disease.

METHODS: We performed a non systematic literature review of the most relevant features of this pathology.

RESULTS: LAPC is more aggressive than organ confined disease. Its clinical diagnosis is not always easy. Local treatment, in spite of being aggressive with potential sequelae, seems to be advantageous in terms of patient survival.

CONCLUSIONS: Prostate cancer local staging is currently based on multiparametric magnetic resonance imaging (mpMRI). Local radical treatment with surgery or radiotherapy, with probable addition of systemic treatment, offers promising results for disease control and quality of life improvement.

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