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Artículo Tomo 71, Número. 7, Septiembre 2018

Archivos Españoles de Urología

Relationship between anogenital distance and prognosis of prostate cancer.

Authors: Carlos Sánchez-Rodríguez, Julián Oñate-Celdrán, Damián García-Escudero, Paula Samper- Mateo, Olimpia Molina-Hernández, Marcos Torres-Roca, Ana Belén Maldonado-Cárceles, José Juan López-Espín, Francisco Martínez- Díaz, Jaime Mendiola-Olivares y Alberto Manuel Torres-Cantero.

Arch. Esp. Urol. 2018; 71 (7): 575-582

Vol. 71, Number. 7, September 2018

OBJECTIVE: Anogenital distance (AGD), the distance from the centre of the anus to the genitals, is a sexually dimorphic phenotype in mammals. Several experimental studies have demonstrated that AGD is a biomarker of prenatal androgen exposure during the masculinisation period of development. The objective of this study was to assess the relationship between AGD (as an indirect marker of prenatal hormonal environment) and severity of the surgical specimen and prostate cancer (PCa) prognosis. METHODS: We conducted a cross-sectional study with a total of 119 PCa patients with confirmed biopsy of the tumour. Every participant underwent a physical examination where two variants of the AGD were assessed, a) from the anus to the cephalad insertion of the penis (AGDAP) and b) to the posterior base of the scrotum (AGDAS). To assess the association between both AGD and severity and PCa prognosis multiple logistic regression analysis was used. RESULTS: Longer AGDAS was significantly associated with biochemical recurrence and affected margins of the surgical specimen (OR: 2.5; IC 95%:1.2-5.5, and 2.8; IC 95%: 1.1-7.5, respectively). CONCLUSIONS: Our findings suggest that a higher prenatal androgen exposure, resulting in a longer AGD, is associated with worse prognosis of PCa.

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