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Artículo Tomo 71, Número. 2, Marzo 2018

Archivos Españoles de Urología

Small cell bladder carcinoma in age extremes: Report of two cases.

Authors: Ana Vallejo-Benítez, Enrique Rodríguez-Zarco, Sara Pabón-Carrasco y Paula Sofía Espinal.

Arch. Esp. Urol. 2018; 71 (2): 204-207

Vol. 71, Number. 2, March 2018

OBJECTIVE: We report 2 cases of small cell neuroendocrine carcinomas (CCP) of the urinary bladder in patients aged 37 and 80 years. CCP is a malignancy with poor prognosis. We review the literature, under the current WHO classification (2016).

METHODS: Paraffin blocks were cut for HE staining and immunohistochemistry to analyze the expression of neuroendocrine differentiation.

RESULTS: The main diagnosis was based on histopathologic features, which revealed a diffuse growth pattern of small cells with scant cytoplasm and hyperchromatic nuclei. The result of the additional technical immunoreaction was positive for synaptophysin and CD56.

CONCLUSIONS: Our cases have been reviewed with the literature to discuss the evolution and differential diagnosis of small cell carcinoma of the urinary bladder. This is a rare tumor with very aggressive behavior and its diagnosis lies in its morphology, and immunohistochemical profile.

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