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Artículo Tomo 70, Número. 2, Marzo 2017

Archivos Españoles de Urología

Recurrent urinary tract infections: prevention of recurrence with intravesical instillations of chondroitin sulfate and hyaluronic acid.

Authors: Jesús Ignacio Tornero Ruiz, Gloria Martínez Gómez, José Félix Escudero Bregante y Guillermo Antonio Gómez Gómez.

Arch. Esp. Urol. 2017; 70 (2): 288-293

Vol. 70, Number. 2, March 2017

OBJECTIVE: The aim of our study is to demonstrate that intravesical administration of the association chondroitin sulfate (CS) and hyaluronic acid (HA), according to our treatment schedule, is a benefit for women with recurrent urinary tract infections (RUTI), not only from a clinical point of view, but also reducing recurrences.

METHODS: This is a study of 28 women diagnosed with RUTI, with a positive culture, and compatible symptoms; frethey underwent treatment according to the protocol of intravesical instillations of the combination CS 2%-1 gr + HA 1.6%-800 mg. To evaluate the effectiveness of the treatment, symptoms improvement, reduction of the number of episodes of urinary tract infection and quality of life were considered.

RESULTS: In our series, we can observe an improvement of the quality of life assessed by PG-I, 66% after 12 months. It was seen that 55.6% of the patient`s urine cultures became negative, while 44.4% had episodes of urinary infection, but with lower baseline symptoms intensity.

DISCUSSION: Patients included in the protocol of instillation improved significantly their quality of life; in addition, to a considerable extent new urinary infections were not presented, being milder when they presented.

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